Seminar Series: Greg Wang

Greg Wang, professor in the Pharmacology and Cancer Biology department at Duke University, will be a speaker for the Purdue Institute for Cancer Research 2025-26 Seminar Series.

Title: Chromatin dysregulation, a cancer driver

“Our research programs focus on a mechanistic understanding of how chemical modifications of chromatin, including methylation of DNA and histone tails, regulate gene expression and cell fate determination during normal development, and how their deregulation leads to human disease. Using biochemical approaches, our laboratory has identified and characterized novel proteins that specifically bind to histone lysine methylation. These histone modification “readers” are critically involved in gene and genome regulation, cell lineage specification, and cancerous transformation. Importantly, the discovery of small-molecule inhibitors that target chromatin modulators has become an area of intensive investigation and holds great promise for therapeutic development. Our goal is to generate potential drug candidates using preclinical cancer models, paving the way for translating new therapeutic approaches in the future. During this visit, I will report on our recent research progress in these areas. For more information, please visit the lab website.”

The event is hosted by Nathaniel Mabe.